Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-
VR23
CAS: 1624602-30-7
Molecular Formula: C19H16ClN5O6S
Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]- - Names and Identifiers
Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]- - Physico-chemical Properties
| Molecular Formula | C19H16ClN5O6S |
| Molar Mass | 477.88 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| In vitro study | VR23 induces accumulation of ubiquitinated proteins in HeLa cells. In RPMI 8226 and KAS 6 cells, VR23 inhibited cell growth with an IC50 of 2.94 and 1.46 μm, respectively. VR23 was as effective against bortezomib (BTZ)-sensitive and resistant RPMI 8226 as ANBL6 cells. In the above cells, VR23 showed a synergistic effect on cell growth inhibition when used in combination with bortezomib. Furthermore, VR23 selectively induces cancer cell apoptosis by causing accumulation of ubiquitinated cyclin E. |
| In vivo study | VR23 (30mg/kg, I. p.) showed potent anti-tumor and anti-angiogenic activity in ATH490 athymic mice inoculated with MDA-MB-231 metastatic breast cancer cells. In mice, VR23 also reduced the side effects caused by paclitaxel. |
Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.093 ml | 10.463 ml | 20.926 ml |
| 5 mM | 0.419 ml | 2.093 ml | 4.185 ml |
| 10 mM | 0.209 ml | 1.046 ml | 2.093 ml |
| 5 mM | 0.042 ml | 0.209 ml | 0.419 ml |
Last Update：2024-01-02 23:10:35
Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]- - Reference Information
| biological activity | VR23 is a potent proteome inhibitor that acts on the trypsin-like proteasome, and the caspase-like proteasome have an IC50 of 1 nM,50-100 nM, and 3 μm, respectively. |
| Target | TargetValue Trypsin-like protasomes (in Hela cells) 1 nM Chymotrypsin-like protasomes (in Hela cells) 100 nM Caspase-like proteasomes (in Hela cells) 3 μm |
| Target | Value |
| Trypsin-like proteasomes (in Hela cells) | 1 nM |
| Chymotrypsin-like proteasomes (in Hela cells) | 100 nM |
| Caspase-like proteasomes (in Hela cells) | 3 μM |
| in vitro study | VR23 induces ubiquitinated protein accumulation in HeLa cells. In RPMI 8226 and KAS 6 cells, VR23 inhibited cell growth with an IC50 of 2.94 and 1.46 μm, respectively. VR23 was as effective against bortezomib (BTZ)-sensitive and resistant RPMI 8226 as ANBL6 cells. In the above cells, VR23 showed a synergistic effect on cell growth inhibition when used in combination with bortezomib. Furthermore, VR23 selectively induces cancer cell apoptosis by causing accumulation of ubiquitinated cyclin E. |
| in vivo study | in ATH490 athymic mice inoculated with MDA-MB-231 metastatic breast cancer cells, VR23 (30mg/kg, I. p.) exhibits potent anti-tumor and anti-angiogenic activity. In mice, VR23 also reduced the side effects caused by paclitaxel. |
Last Update：2024-04-10 22:29:15
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Product Name: VR23 Visit Supplier Webpage Request for quotationCAS: 1624602-30-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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